England bowlers Stuart Broad and Graeme Swann are poised to make their return for Nottinghamshire this week.
The game against Lancashire at Old Trafford will be Broad's first since recovering from a calf strain suffered on England's tour of Sri Lanka.
Broad, 25, flew home after sustaining the injury during the first Test defeat in Colombo in March.
The duo could also play against Middlesex next week in preparation for England's series against West Indies.
"Graeme is ready to play and will slot straight in but Stuart hasn't had any competitive cricket for a month," said Notts director of cricket Mick Newell.
"We all know what they are capable of and they need to use these games to prepare for a big summer of international cricket."
The first Test of the three-match series against West Indies is at Lord's, beginning on 17 May.
The second Test, at Trent Bridge, starts on 25 May, with the series concluding at Edgbaston from 7 June.
England then play the tourists in three one-day internationals with Broad set to captain the world champions in the sole Twenty20 game at Trent Bridge on 24 June.
Paceman James Anderson is in the Lancashire squad for his first domestic appearance of the season, while elsewhere, opener Alastair Cook will line up for Essex against Glamorgan.
BROAD AND SWANN MAKE NOTTS RETURN
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Stuart Broad, whose enforced absence goes back six weeks to the calf strain that curtailed his Sri Lanka tour, was also wicketless, having earlier risked another stain on his disciplinary record when making his feelings clearly known after being given out first ball.
The Nottinghamshire player disputed Steven Croft's claim to have caught him cleanly at short leg as he tried to sweep the left-arm spinner Simon Kerrigan. Lancashire celebrated en masse but Broad stood his ground as umpire Stephen Gale consulted colleague Rob Bailey at square leg and then appeared to aim words at both Croft and Gale as reluctantly he walked off.
Gale encountered more disagreement only minutes later when Graeme Swann, another England player making his first domestic appearance of the season, stared at him in disbelief after being given out leg before to Kerrigan.
Mick Newell, Nottinghamshire's director of cricket, said he believed Broad would not face any action. "He has seen the umpires and said he didn't feel his behaviour was unacceptable and they have not come to us to say it was, which they would normally have done, so hopefully that is the matter closed."